5 edition of molecular and ionic signaling of neutrophils found in the catalog.
molecular and ionic signaling of neutrophils
Maurice B. Hallett
Includes bibliographical references and index.
|Statement||Maurice B. Hallett, Darren Lloyds.|
|Series||Molecular biology intelligence unit, Molecular biology intelligence unit (Unnumbered)|
|Contributions||Lloyds, Darren, 1968-|
|LC Classifications||QR185.8.N47 H35 1997|
|The Physical Object|
|Pagination||212 p. :|
|Number of Pages||212|
|ISBN 10||1570594635, 0412147912|
|LC Control Number||97020920|
Most of Rho functions and signaling events were revealed in the fibroblasts, but similar processes apparently occur in neutrophils and other types of cells. Simoes et al. demonstrated LXA4 receptor (FPR2) coupled with Rho/Rho kinase pathway and MAPK cascade to activate chemotaxis in human monocytes .Cited by: To date, six human α-defensins have been identified. The first four, also known as human neutrophil peptides 1–4 or HNPs 1–4, are abundant in the azurophilic granules of neutrophils ;, while human α defensins 5 and 6, also known as HD5 and HD6, are mainly expressed in intestinal Paneth cells ;.Cited by:
PMA-stimulated Tyr phosphorylation in neutrophils is reduced by alcohol pretreatment. A, neutrophils (5 10 6 cells/ml) were pretreated with buffer (lane . Polymorphonuclear neutrophils (PMNs) are the most abundant leukocytes in the blood and are considered as the first line of innate immune defence against infectious diseases. However, PMN cells have a crucial function in both innate and adaptive immune responses. Neutrophils have several mechanisms to control pathogens, and one of them is their capability to form neutrophil Author: Maximina B. Moreno-Altamirano, Christian E. Cruz-Gómez, Lluvia E. López-Luis.
In addition, neutrophils represent a unique model for studying fundamental questions of cellular biochemistry and molecular biology. This monograph provides a detailed description of signal transduction, generation of reactive oxygen, and mechanisms of migration and death of these cells. Reactive oxygen and nitrogen species as signaling molecules regulating neutrophil function Article Literature Review in Free Radical Biology and Medicine 42(2) .
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Additional Physical Format: Online version: Hallett, Maurice B. (Maurice Bartlett), Molecular and ionic signaling of neutrophils.
Austin. Tex. Neutrophils, the most abundant white cells in humans, serve as the primary cellular defense against infection. Neutrophil Methods and Protocols, Second Edition provides a concise set of protocols written by leading researchers in the field for assessing basic neutrophil functions, investigating specialized areas in neutrophil research, and completing step diagnostic assays of common neutrophil.
A peptide secreted by neurons that functions as a signaling molecule either at a synapse or elsewhere. These molecules have diverse, often long-lived effects in contrast to neurotransmitters.
neurotransmitter. Extracellular signaling molecule that is released by the presynaptic neuron at a chemical synapse and. Perhaps the most important feature of neutrophils is their ability to rapidly change shape.
In the bloodstream, the neutrophils circulate as almost spherical cells, with the ability to deform in order to pass along narrower capillaries. Upon receiving the signal to extravasate, they are able to transform their morphology and flatten onto the endothelium by: 7.
In book: Neutrophil, pp electrogenic oxidase is also governed by ionic fluxes, which are constrained at phagosomes due molecular and ionic signaling of neutrophils book low intraphagosomal volume.
Signal transduction third edition further elaborates on diverse signaling cascades within particular contexts such as muscle contraction, innate and adaptive immunity, glucose metabolism, regulation of appetite, oncogenic transformation and cell fate decision during development or in stem cell niches.
The subjects have been enriched with. In B cells however, proton channels play a cell signaling role, because H 2 O 2 diffuses back across the B-cell membrane to oxidize and inactivate SHP-1, a protein tyrosine phosphatase that negatively regulates the signaling cascade initiated by the binding of antigens to the B cell receptor (Capasso et al., ).Cited by: In order to define the molecular pathways sensitive to the intracellular increase of free Ca 2+, stimulation of neutrophils by fMLP-OMe and [Δ z Leu 2] were studied in normal conditions as compared to extracellular Ca 2+-free by: Neutrophils are an essential cell type in the innate immune system necessary for the clearance of bacterial pathogens.
Their critical role is demonstrated by the profound immunodeficiency of individuals with neutropenia, or low circulating neutrophil numbers, Cited by: Immunoreceptors on neutrophils.
paired-receptor system on human neutrophils has remained unclear because of the lack of specific molecular tools. additional neutrophil signaling pathways.
The protocols follow the successful Methods in Molecular Biology™ series format, each offering step-by-step laboratory instructions, an introduction outlining the principles behind the technique, lists of the necessary equipment and reagents, and.
Diacylglycerol kinases (DGKs) play a key role in phosphoinositide signaling by removing diacylglycerol and generating phosphatidic acid. Besides the well-documented role of DGKα and DGKζ as negative regulators of lymphocyte responses, a robust body of literature points to those enzymes, and specifically DGKα, as crucial regulators of leukocyte function.
Upon neutrophil Author: Gianluca Baldanzi, Mario Malerba. Part of the Methods in Molecular Biology book series (MIMB, volume 27) Abstract Movement of ions across cell membranes is associated with processes such as cell signaling, regulation of cell volume, maintenance of cell composition and pH, and energy : C.
Lindsay Bashford. Interdisciplinarity is more often invoked than practised. This is hardly surprising, considering the daunting vastness of modern biology. To reach a satisfactory understanding of a complex biological system, a wide spectrum of conceptual and experimental tools must be applied at different levels, from the molecular to the cellular, tissue and organismic.
His publications include The Neutrophil: Cellular Biochemistry and Physiology, The Molecular and Ionic Signaling of Neutrophils, Localised PtdIns(3,4,5)P 3 or PtdIns(3,4)P 2 at the phagocytic cup is required for both phagosome closure and Ca 2+ signalling in HL60 neutrophils in Journal of Cell Science, The use of single image random dot stereograms for presenting 3D.
The consequent rise in ionic strength engenders the release of cationic granule proteins, including elastase and cathepsin G, from the anionic sulphated proteoglycan matrix.
Possible molecular processes to focus on would be the signaling pathways and clearance of NETs during these ocular pathologies. Furthermore, the discussed open questions should be answered in the future using complex 3D cell culture system that Cited by: 2.
Macrophages are shown to promote reverse migration through neutrophil redox-Src family kinase signaling, whereas Src deficiency impairs neutrophil RTEM.
This might represent another mechanism of macrophage clearance of neutrophils, in addition to macrophage phagocytosis of apoptotic by: 1. Molecular biology of the cell by Alberts, Bruce. Membrane transport of small molecules and the ionic basis of membrane excitability -- Intracellular compartments and protein sorting -- Vesicular traffic in the secretory and endocytic pathways -- Energy conversion: Mitochondria and chloroplasts -- Cell signaling -- The cytoskeleton -- The.
Ca 2+-dependent production of reactive oxygen metabolites by human neutrophils in response to fluorinated propranolol analogues. The molecular and ionic signaling of neutrophils. Molecular biology intelligence unit. Springer: New York, p. – Cited by: 3. Signal transduction is the process by which a chemical or physical signal is transmitted through a cell as a series of molecular events, most commonly protein phosphorylation catalyzed by protein kinases, which ultimately results in a cellular response.
Proteins responsible for detecting stimuli are generally termed receptors, although in some cases the term sensor is used. The .One mechanism of antimicrobial defense by neutrophils is the formation of neutrophil extracellular traps (NETs), which are composed of DNA and antimicrobial proteins.
Research has demonstrated that these NETs may also contribute to endothelial injury. The emerging fungal pathogen Candida auris has produced numerous outbreaks of invasive disease in hospitals worldwide.
Why this species causes deadly disease is unknown. Our findings reveal a failure of neutrophils to kill C. auris compared to the most commonly encountered Candida species, C. albicans. While neutrophils produce neutrophil Cited by: